Electric Literature of 174913-12-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 174913-12-3, name is 1-Bromo-3-chloro-5-methoxybenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1-bromo-3-chloro-5-methoxybenzene benzene (835 mg, 3.77 mmol), and i,3,5-trichloro-i,3,5- triazinane-2,4,6-trione (299 mg, 1.29 mmol) in DMF (18 mL) was stirred 16 h under N2 and 50 C. Afier cooling to RT, the reaction mixture was diluted with aqueous NH4C1 and extracted with Et20. The combined organic phases were dried over Mg504, filtered, concentrated, and the resultingresidue was purified by silica chromatography (0 to 25% gradient of EtOAc/heptane) to 1 -bromo-2,3-dichioro-5- methoxybenzene (720 mg, 2.81 mmol). ?H NMR (400 MHz, CHLOROFORM-d) oe ppm 7.14 (d, J=2.76 Hz, 1H), 7.01 (d, J=3.01 Hz, 1H), 3.81 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-chloro-5-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Chloride – Wikipedia,
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