In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7781-10-4, name is 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
To a solution of 2,2,6,6-tetramethylpiperidine (92 uL, 0.54mmol) in THF (4 mL)at -10C, R-BuLi (338 uL, 1.6M in hexane, 0.54mmol) was added drop wise and thereaction mixture was stirred at -10C for 10 min. Compound 33 (60mg, 0.36mmol) [G. B.Evans et al. J. Ore. Chem.. 2001. 66.17. 5723-5730 and shown in the scheme 6] was addeddrop wise maintaining the temperature below -70C over a period of 15 min. Dried CC^-gaswas bubbled through the reaction mixture and stirred at room temperature overnight. Theprecipitate thus formed was collected by filtration and dried to afford the title compound275 (78mg, 100% yield) as a yellow solid. MS (m/z): 209.9 (RCOOH, M-H) (found).Step 2. 4-Chloro-A^^,7-trimethyl-7^-pyrrolo[2,3-cOpyrirnidine-6-carboxamide (276)
The synthetic route of 7781-10-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; METHYLGENE, INC.; WO2006/10264; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics