Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106131-61-7, name is 3,6-Dichloro-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Safety of 3,6-Dichloro-1,2,4,5-tetrazine
Dichloro-s-tetrazine (1.50 g,10 mmol) and allyl alcohol (0.68 mL, 10 mmol) were dissolved in 100mL of anhydrous dichloromethane. 2,4,6-collidine (1.32 mL, 10 mmol) was added dropwise at room temperature in the solution, and the mixture was stirred for 1 h 30 min under N2 atmosphere. The solvent was evaporated andthe residue was passed through a column of silica (2/8 dichloromethane/petroleum ether v/v) to give 1.42 g (82%) of compound 1. 1H NMR (CDCl3) delta (ppm) 6.13 (m, 1H, CH), 5.57 (d, 1H, 3J 17.4 Hz, CH=CH2), 5.44 (d, 1H, 3J 10.5 Hz, CH=CH2), 5.18 (d, 2H, CH2, 3J 6.0 Hz). 13C NMR (CDCl3) delta (ppm) 166.6 (CTz-Cl), 164.6 (CTz-O), 130.3 (CH=CH2), 121.1 (CH=CH2), 71.0 (O-CH2).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ben Chaabane, Radhia; Guermazi, Refka; Clavier, Gilles; Audebert, Pierre; Hedhli, Ahmed; Dyes and Pigments; vol. 108; (2014); p. 64 – 69;,
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