These common heterocyclic compound, 2268-05-5, name is 2,6-Dichlorofluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3Cl2F
To a solution of 19 (3.0 g, 14.0 mmol) in NMP (20 mL) was added K2CO3 (5.80 g, 41.9 mmol) and 1,3-dichloro-2-fluoro-benzene (26, 2.31 g, 14.0 mmol). The reaction was heated to 120 C. overnight. The reaction mixture was cooled to RT, diluted with H2O and extracted 3 times with EtOAc. The combined extracts were washed with H2O and brine, dried (Na2SO4), filtered and evaporated in vacuo to afford 27 which was used in subsequent steps without further purifications.
The synthetic route of 2,6-Dichlorofluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Roche Palo Alto LLC; US2007/88053; (2007); A1;,
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