Related Products of 626-43-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-43-7, name is 3,5-Dichloroaniline, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of bromo acetyl bromide (3.3 g, 16.41 mmol) in CH2C12 (15 mL) was added 3, 5-dichloroaniline 1 (2.65 g, 16.41 mmol) in CH2C12 (10 mL) for 10 mm at RT and stirred for 30 mm. The reaction progress was monitored by TLC; after reaction completion, the volatile reagents and solvent were removed under reduced pressure. The residue was diluted with water (40 mL) and extracted with CH2C12 (2 x 40 mL). The combined organic extracts were dried over Na2SO4, filtered and concentrated under reduced pressure to obtain compound 2 (3.8 g, 65%) as an off-white solid. 1H NMR (500 MHz, CDC13): oe 8.13 (br s, 1H), 7.51 (s, 2H), 7.16 (s, 1H), 4.01 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 3,5-Dichloroaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PHARMAKEA, INC.; HUTCHINSON, John, Howard; LONERGAN, David; HUANG, Fei; ROWBOTTOM, Martin; CALDERON, Imelda; WO2015/48301; (2015); A1;,
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