Reference of 19393-92-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19393-92-1 as follows.
EXAMPLE 263 (+-)-{[5-chloro-7-(2,6-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}amine The title compound was prepared (0.072 g, 8percent) following the general procedure of Example 166 as a white solid, hydrochloride salt from (5-chloro-2-methoxyphenyl)boronic acid (5.0 g, 26.88 mmol) and 2-bromo-1,3-dichlorobenzene (12.14 g, 53.76 mmol). mp 234-236° C.
According to the analysis of related databases, 19393-92-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wyeth; US2005/261347; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics