Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-50-5, name is 4-Chloro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Chloro-2-methoxyaniline
Example 57; 4-(4-Chloro-2-methoxy-phenyl)-3-(4-ethoxy-phenyl)-5-methyl-4H-[1,2,4]triazole; The products of preparations 4 (1g, 4. 9mmol) and 91 (926mg, 5. 88mmol) were dissolved in xylene (20ml) and the reaction mixture was heated for 10 hours at 150C. Heating was continued for 4.5 hours with portions of para-toluenesulfonic acid (100mg) added to the mixture at regular intervals until tic analysis showed all of the starting material to be consumed. The reaction mixture was then taken up into 2N hydrochloric acid and ethyl acetate and partitioned. The aqueous layer was basified with sodium hydroxide pellets and re-extracted with ethyl acetate. The combined organic phase was dried over sodium sulfate and evaporated to give a dark brown oil. Trituration with diethyl ether formed a dark brown solid that was re-crystallised from ethyl acetate to produce the title compound as a beige solid (340mg). Evaporation of the ethyl acetate gave a further residue that was purified by column chromatography on silica gel, eluting with dichloromethane : methanol : 0.88 ammonia, 98.2 : 0.2, to afford further amounts of product giving a total yield of 37% (629mg). ‘H NMR (CDCI3, 400MHz) d : 1.39 (t, 3H), 2.27 (s, 3H), 3.73 (s, 3H), 3.99 (q, 2H), 6.78 (d, 2H), 7.02-7. 06 (m, 3H), 7.31 (d, 2H). MS APCI+ m/z 344 [MH] +
According to the analysis of related databases, 93-50-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics