Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, Safety of 3,5-Dibromochlorobenzene
3-cyanophenyl boronic acid (25.0 g, 0.17 mol) and 1,3-dibromo-5-chlorobenzene (23.0 g, 0.08 mol) Dissolved in 290 mL of tetrahydrofuran, 1.5 M aqueous potassium carbonate solution (90 mL) was added,Tetrakis- (triphenylphosphine) palladium (3.94 g, 0.34 mmol) was added thereto, followed by heating with stirring for 13 hours.The temperature was lowered to room temperature, the water layer was separated off, dried over anhydrous magnesium sulfate and concentrated under reduced pressureRecrystallization was performed using chloroform and ethanolWas dried to prepare the intermediate n (44.7 g, yield 83%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromochlorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Moon Jeong-uk; Jeong Min-u; Lee Dong-hun; Chae Mi-yeong; (49 pag.)KR2018/32517; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics