Reference of 39226-96-5, These common heterocyclic compound, 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 102 : 4-Chloro-6-(2-chloro-3-trifluoromethyl-benzylamino)-2H-phthalazin- 1-one; A mixture 6-bromo-4-chloro-2H-phthalazin-l-one (150 mg, 0.58 mmol), 2- chloro-3-trifluoromethyl-benzylamine (124 mg, 0.64 mmol), Pd2(dba)3 (53 mg, 0.058 mmol), rac-BINAP (132 mg, 0.17 mmol) and NaOr-Bu (140 mg, 1.45 mmol) in DMA (6 mL) was heated at 8O0C for Ih. The mixture was allowed to cool, diluted with EtOAc (25 mL) and washed with water (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated. Chromatography on silica (EtOAc/hexanes) yielded the title compound. 4-Chloro-6-(2-chloro-3-trifluoromethyl-benzylamino)-2H-phthalazin- 1 – one: 38 mg (17.6%): m/z (M+eta)=372. 1H-NMR (DMSO-^) delta: 12.38 (s,lH), 7.95 (d,lH), 7.71 (m, 3H), 7.39 (m,lH), 7.19 (dd,lH), 6.85 (s,lH), 4.57 (d,2H).
Statistics shows that (2-Chloro-3-(trifluoromethyl)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 39226-96-5.
Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
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