Synthetic Route of 13078-79-0,Some common heterocyclic compound, 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 26 (100mg, 0.27mmol), 4-tolylmethanamine (100mg, 0.08mL, 0.81mmol), BOP reagent (120mg, 0.27mmol), and triethylamine (80mg, 0.11mL, 0.81mmol) in anhydrous DMF (5mL) was stirred at 25C for 12h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with brine, dried and filtered. Removal of the solvent gave a residue that was purified by column chromatography (silica gel, ethyl acetate:n-hexane=1:2 as eluent) to furnish 4 (70mg, 56%), mp 240-242C (from ethanol).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3-Chlorophenyl)ethanamine, its application will become more common.
Reference:
Article; Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, Sveva; Brancale, Andrea; Maga, Giovanni; Crespan, Emmanuele; Badia, Roger; Clotet, Bonaventura; Este, Jose A.; Cirilli, Roberto; Novellino, Ettore; Silvestri, Romano; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 101 – 111;,
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