Synthetic Route of 63624-28-2, These common heterocyclic compound, 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of ethyl 6-amino-9-ethyl-1-methyl–carboline-3-carboxylate 11a (1.0 mmol) and 3,4-dimethoxybenzene sulfonylchloride (1.0 mmol) in DMF (5 mL) was stirred for 5min at room temperature, followed by the addition of pyridine(4.0 mmol) was added. The mixture was stirred for an additional0.5 h. After adding ice water (10 mL), the mixture wasextracted with EtOAc (320 mL). The organic phase waswashed with brine (220 mL), dried over anhydrous Na2SO4,and concentrated in vacuum. The residue was purified oversilica column chromatography using petroleum ether (PE) :EtOAc (1:1, v/v) as eluent to afford the title compound 12a.
Statistics shows that 2,4-Dimethoxybenzene-1-sulfonyl chloride is playing an increasingly important role. we look forward to future research findings about 63624-28-2.
Reference:
Article; Chen, Jing; Du, Wenting; Tao, Xuefen; Huang, Jiawei; Song, Yuliang; Ying, Huazhou; Letters in drug design and discovery; vol. 10; 9; (2013); p. 879 – 885;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics