These common heterocyclic compound, 104-52-9, name is 3-Phenylpropyl Chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-Phenylpropyl Chloride
(1) 1-Bromo-3-chloro-1-phenylpropane 3-Chloro-1-phenylpropane (3.09 g, 20 mmol.), N-bromosuccinimide (3.56 g, 20 mmol.), benzoyl peroxide (catalytic amount), and carbon tetrachloride (30 mL) were mixed, and the resulting mixture was heated to reflux for 15 min while it was exposed to a light of 100V/100 W, to perform a reaction. Insolubles were filtered off. The reaction liquid was washed with an aqueous saturated sodium hydrogen carbonate solution and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate, and placed under reduced pressure to distill the solvent off, to give 4.58 g of the desired compound (yield 98%) as an oil. 1 H-NMR (CDCl3) delta: 2.1-2.9 (2H, m), 3.3-3.9 (2H, m), 5.16 (1H, dd, J=7 Hz, 10 Hz), 7.1-7.5 (5H, m).
The synthetic route of 3-Phenylpropyl Chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nippon Chemiphar Co., Ltd.; US5773437; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics