Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, A new synthetic method of this compound is introduced below., Safety of 3-Chloro-2-chloromethyl-1-propene
Example 3 12,13-(2-methylene-propan-1,3-yl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole (Compound 22) 12,13-(2-hydroxymethyl-propan-1,3-yl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole (Compound 23) 9-hydroxymethyl-12,13-(2-hydroxymethyl-propan-1,3-yl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole (Compound 212) Compound 1c (1.56 g, 5.0 mmol, 1.0 equiv) was added to Cs2CO3 (4.89 g, 15.0 mmol, 3.0 equiv) in DMF (20 mL) under N2 at room temperature. The mixture was stirred for 5 min, then 3-chloro-2-chloromethyl-prop-1-ene (625 mg, 5.0 mmol, 1.0 equiv) was added. The mixture was stirred at rt for 24 hours and poured into H2O (200 mL). The resulting yellow solid was filtered and washed with H2O (50 mL×2) and Et2O/hexane (1:1, 50 mL×3), then dried in vacuo to provide Compound 22 (1.46 g, 80%) as a yellow solid. 1H NMR: (d6-DMSO) delta 4.96 (s, 2H), 5.28 (s, 2H), 5.30 (s, 2H), 5.80 (s, 2H), 7.28 (t, 1H, J=8.1 Hz), 7.37 (t, 1H, J=7.2 Hz), 7.52 (t, 1H, J=8.1 Hz), 7.57 (t, 1H, J=8.1 Hz), 7.81 (d, 1H, J=8.1 Hz), 7.87 (d, 1H, J=7.8 Hz), 8.07 (d, 1H, J=7.2 Hz), 8.53 (s, 1H), 9.31 (d, 1H, J=7.8 Hz). MS m/z 386 (M+Na), 364 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Wilson, Lawrence J.; Murray, William V.; Yang, Shyh-Ming; Yang, Cangming; Wang, Bingbing; US2007/249590; (2007); A1;,
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