Electric Literature of 367-22-6,Some common heterocyclic compound, 367-22-6, name is 4-Chloro-3-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Compound 7 (488.2 mg, 2.0 mmol), 3,4-dimethoxybenzenamine 8a (367.6 mg, 2.4 mmol), and p-toluenesulfonic acid monohydrate (304.4 mg, 1.6 mmol) were dissolved in n-butanol (20 mL), then refluxed at 130 oC for 12 h. The resulting solution was neutralized with saturated NaHCO3 (5 mL). The mixture was extracted with ethyl acetate (50 mL×3). The organic layer was combined, dried over anhydrous Na2SO4, concentrated. The crude product was purified by silica gel chromatography to afford 9a (319.7 mg, 44.3% yield).
The synthetic route of 367-22-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Long, Liang; Luo, Yu; Hou, Zhi-Jie; Ma, Hua-Juan; Long, Zi-Jie; Tu, Zheng-Chao; Huang, Lin-Jie; Liu, Quentin; Lu, Gui; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 805 – 812;,
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