In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1127-85-1, name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline
2,4-Dichloro-5,6,7,8-tetrahydroquinazoline(103 mg, 0.640 mmol) and K2CO3 (265 mg, 1.92 mmol) were dissolved in DMF (3.2 ml), and then 3-fluorobenzenethiol (110 mg, 0.767 mmol) was slowly added dropwise and stirred at room temperature for 2 hours .After confirming the termination of the reaction, the reaction solution was diluted with dichloromethane and extracted several times with distilled water. The separated organic layer was dried over anhydrous MgSO4, filtered under reduced pressure, and concentrated.The concentrated filtrate was separated and purified by silica gel column chromatography (Hex: EtOAc = 18: 1) and purified to obtain the desired compound (181 mg, 96%) as a white solid.
The synthetic route of 1127-85-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; Nam, Ghil-Soo; Choo, Hyun-Ah; Choi, Kyung-Il; (40 pag.)KR101730790; (2017); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics