Adding a certain compound to certain chemical reactions, such as: 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19752-55-7, category: chlorides-buliding-blocks
Example S.3: Synthesis of 3,5-dichloro-2,2,2-trifluoro acetophenone (Compound example no.2 of table C.1 ); To 5.1 g (0.209 mol) Magnesium turnings was added 0.45 g of a 1 molar solution of DIBAL in hexane at 6O0C. After 15 min, 3,5-dichloro-bromobenzene (5.0 g, 0.022 mol) and 25 mL THF were added and the mixture was stirred. After start up of the reaction a mixture of 45g (0.2 mol) 3,5-dichloro-bromobenzene and 250 mL THF was added under reflux. After completion of the reaction the mixture was cooled to 00C and 31.1 g (0.219 mol) ethyl trifluoroacetate was added. After 2 h an aqueous solution of NH4CI was added an the mixture was separated between MTBE and aqueous NH4CI solution. The organic layer was separated and the solvent was removed in vacuum. (34.3g brown oil; purity 70percent ace. to g.c; yield 50percent)1H-NMR (360 MHz, CDCI3): delta = 7.7 (s, 1 H), 7.9 (s, 2H) ppm.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; BASF SE; Rack, Michael; Koerber, Karsten; WO2010/125130; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics