Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-chloromethyl-1-propene
Add NaH (8.4 g, 0.352 mol, 4.4 eq.) to a 500 mL oblique vial.Add 250 mL in sequence under an argon atmosphereNew steamed anhydrous THFAnd 1-dodecyl alcohol (31 g, 0.167 mol, 2.1 eq.),Stir at room temperature,Additional 3-chloro-2-chloromethylpropene (10 g, 0.08 mol, 1 eq.) was added.Finally, the temperature was raised to 65 C and reacted overnight.After the reaction solution is cooled to room temperature,Slowly adding ethanol to quench the reaction,Spin the THF,The reaction solution was extracted with CH 2 Cl 2 and washed with water.Dried over anhydrous magnesium sulfate,Filtered, concentrated, and purified on silica gel column(eluent: PE/CH2Cl2 = 5/1) gave a colorless liquid 25 g, yield 75%.
The synthetic route of 1871-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Donghua University; Zhang Dengqing; Yang Linghui; Li Xianying; (22 pag.)CN109336894; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics