Month: June 2021

Application of 50594-82-6,Some common heterocyclic compound, 50594-82-6, name is 3,4,5-Trichlorobenzotrifluoride, molecular formula is C7H2Cl3F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PRODUCTION EXAMPLE 3 (Production of Compound No. (3)) After 44 mg (1.1 mmol) of 60% sodium hydride was added to a solution of 0.14 g (1 mmol) of 5-(1-methylcyclopropyl)-1,3,4-oxadiazolin-2-one in 5 ml of N,N-dimethylformamide at room temperature, the mixture was stirred at the same temperature for 15 minutes. To the mixture was added 0.25 g (1 mmol) of 3,4,5-trichlorobenzotrifluoride followed by heating a 80 C. for 6 hours. After cooling, the mixture was poured into water and extracted with ethyl acetate. After drying over magnesium sulfate, the extract was concentrated under reduced pressure to give the crude product. The crude product was subjected to silica gel column chromatography to give 35 mg of 5-(1-methylcyclopropyl)-3-(2,6-dichloro-4-trifluoromethylphenyl)-1,3,4-oxadiazoline-2-one. m.p. 107.1 C.

The synthetic route of 50594-82-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Company, Limited; US5124341; (1992); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6276-54-6, A common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the 3 mL of dichloromethane was added the compound of Example 5 (65 mg, 0.12 mmol)After dissolving 3-chloropropylamine hydrochloride (33 mg, 0.24 mmol) and triethylamine (0.05 mL, 0.37 mmol)And the mixture was stirred at room temperature under a nitrogen atmosphere for 5 hours.After completion of the reaction, Dichloromethane and purified water were added and stirred,The organic layer and the water layer were separated,The water layer was extracted three times with dichloromethane to collect all organic layers.After the water remaining in the organic was removed with magnesium sulfate, Concentrated and purified by silica gel column chromatography (eluent: 5% MeOH-CH2Cl2) to obtain the desired compound as a white solid. (49 mg, 78.6%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BioActs Co., Ltd.; Park, Jin Woo; Choi, Jae-Ho; Kim, Ki Won; Kim, Jinju; (29 pag.)KR2017/60859; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics