Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108-70-3, name is 1,3,5-Trichlorobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H3Cl3
To a 250 ml one-necked flask was added 10.0 g (55.1 mmol) of 1,3,5-trichlorobenzene and 100 ml of ultra-dry tetrahydrofuran under argon gas protection and minus 78 degrees Celsius. Then, 23 ml (2.4 M, 55.2 mmol) of n-butyllithium in n-hexane was added dropwise, and the mixture was stirred at minus 78 C for 30 minutes. Then, 7.44 ml (107.3 mmol) of ultra-dry DMF was added dropwise, and stirring was continued for 1.5 hours at minus 78 C. The reaction was then slowly warmed to room temperature and quenched by the addition of 200 mL (3M) hydrochloric acid. The combined organic layers were washed with brine (25 mL) After evaporating the solvent, it was purified by column chromatography using methylene chloride: petroleum ether 1:1 (yield ratio) as eluent to afford 11.0 g of product A1, yield 95%.
The synthetic route of 108-70-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin University; Li Feng; Ai Xin; Zhang Ming; (25 pag.)CN108191739; (2018); A;,
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