Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, A new synthetic method of this compound is introduced below., SDS of cas: 6579-54-0
The methyl 4-(morpholine-2-carboxamido)adamantine-1-carboxylate compound (174.0 mg, 0.54 mmol) was dissolved in CH2Cl2 (4 ml), and 2,6-dichlorobenzenesulfonyl chloride (132.6 mg, 0.54 mmol) and triethylamine (120.2 mg, 1.19 mmol) were added thereto, followed by stirring at room temperature for 3 hours. H2O was added to the reaction solution, which was then extracted three times with CH2Cl2. The extract was dried with MgSO4, filtered and distilled under reduced pressure to remove the solvent. The residue was separated by column chromatography, thereby obtaining a methyl 4-(4-((2,6-dichlorophenyl)sulfonyl)morpholine-2-carboxamido)adamantane-1-carboxylate compound (243.9 mg, 0.46 mmol, 85 %).[2013] 1H NMR (400 MHz, CDCl3) delta7.53-7.48 (m, 2H), 7.39-7.33 (m, 1H), 6.92 (br, -CONH), 4.15-4.00 (m, 4H), 3.85-3.63 (m, 5H), 3.13-3.06 (m, 1H), 2.90-2.84 (m, 1H), 2.07-1.54 (m, 13H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol; WO2012/128582; (2012); A2;,
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