Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-32-1, name is 2-Chloro-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H8ClN
Examples; General Description General description of the reaction conditions; In a microwave reaction vial (size 0.5-2 ml) fitted with a magnet stirring bar, a solution of 0.5-1.5 mg of the starting ortho-bromo anilines in 250 muL of dry acetonitrile was introduced, followed by the addition of 50 muL of an anhydrous solution of [18F]TBAF in acetonitrile. To the reaction solution, 500 muL of dry acetonitrile was added. The microwave vial was crimped with a Teflon septum, and thereafter purged with argon for 5 min. The resulting reaction vial was kept in the microwave cavity of a microwave system (Initiator EXP, Biotage, Sweden), and heated for 30 min at 180C. The reaction was quenched by cooling the vial with compressed air, after which the contents of the vial were subjected to chromatographic analysis (HPLC with RP18e Chromolith column, internal diameter 4.6 mm; length of 100 mm) eluted with a mixture of acetonitrile/water (27.5 : 72.5% v/v).; Example 1: Model Compounds and Examples of the General Method; Labeling reactions were carried out in acetonitrile in the presence of a tetrabutylammonium salt (TBA+) and [18F]fluoride. Various leaving groups were evaluated. Reaction times were 20-40 minutes, and the reaction temperature was in the range of 150C-200C to result in yields in the range of 7-68% at. The highest yields of 61 +/- 5 % resulted from the use of a ortho-bromo-leaving group and a combination of a reaction temperature of 180C and a reaction time of 30 min. No radioactive by-product except for the desired ortho-[18F]fluorinated aniline derivative has been observed as measured by analytical HPLC. The reactions were according to the general reaction scheme of Scheme 2 below and are summarized in Table 1.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 932-32-1.
Reference:
Patent; Technische Universitaet Muenchen; EP1944281; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics