These common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H11Cl2NO
Preparation of Compound IV:3-Chloro-4-methoxybenzylamine hydrochloride III (25.00 g, 0.12 mol)Suspended in 75mL acetonitrile,Add sodium bicarbonate (23.21 g, 0.27 mol),Compound II (22.02 g, 0.11 mol) was added,Stir at 40 degrees for 2.5 hours.The reaction solution was suction filtered,The filter cake was washed once with 10 mL of acetonitrile.Wash once with 10 mL of water.After the filter cake is dried by phosphorus pentoxide,32.01g of white solid compound IV,The yield was 87.37%.
The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Wu Wenchao; Song Dandan; Zhang Chi; Cui Xilin; (10 pag.)CN110117274; (2019); A;,
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