Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
To a solution of 2,4-dichloropyrrolo[2,l-f [l,2,4]triazine (la) (3 g, 15.96 mmol, CASNo. 918538-05-3) in DMF (50 mL) under Ar atmosphere was added 1 -ethoxy vi nyltri -//-butylti n (7.07 mL, 20.74 mmol, CASNo. 97674-02-7) and bis(triphenylphosphine)Palladium(II)chloride (0.56 g, 0.8 mmol). The mixture was heated with stirring at 100 C for 30 min, cooled to room temp and diluted with EtOAc (150 mL). The reaction mixture was washed with water (50 mL), brine (30 mL), dried, filtered and concentrated in vacuum to dryness. The residue obtained was purified by flash column chromatography [silica (24 g), eluting with EtOAc in hexane from 0-50%] to afford 2-chl oro-4-(l -ethoxy vinyl)pyrrolo[2, l-f][l, 2, 4]triazine (lb) (2.2 g, 62 % yield) as an orange oil; NMR (300 MHz, DMSO-7e) d 8.23 (dd, J= 2.6, 1.4 Hz, 1H), 7.34 (dd, J= 4.7, 1.4 Hz, 1H), 7.11 (dd, j= 4.7, 2.6 Hz, 1H), 5.64 (d, 7= 2.4 Hz, 1H), 4.88 (d, J= 2.4 Hz, 1H), 4.03 (q, J= 7.0 Hz, 2H), 1.44 (t, J= 7.0 Hz, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 918538-05-3.
Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda; ZHANG, Weihe; LU, Pen-Cheng; WU, Minwan; LV, Wei; NGUYEN, Trung, Xuan; DANG, Zhao; CHINTAREDDY, Venkat, R.; KUMAR, V., Satish; RAMAN, Krishnan; (1223 pag.)WO2019/195720; (2019); A1;,
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