Related Products of 622-86-6, These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(4-Nitrophenyl) butanoic acid (1.66 g, 7.9mmol) was dissolved in trifluoroacetic anhydride (1.1 mL, 7.9 mmol), then(2-chloroethoxy)benzene (1.0 ml, 7.2 mmol) was added dropwise. The resultingmixture was allowed to stir at room temperature overnight. The reaction mixture was poured into saturatedaqueous sodium bicarbonate solution (50 mL) and extracted with ethyl acetate (2x 50 mL). The combined organic phases were driedover anhydrous magnesium sulfate and concentrated on a rotaryevaporator. The resulting residue waspurified by chromatography on silica gel (ethyl acetate/hexane) to afford 1.49g (59%) of the desired compound as a white solid. 1HNMR (400 MHz, CDCl3) delta8.21 (d, J = 8.8 Hz, 2H), 7.96 (d, J = 8.9 Hz, 2H), 7.51 (d, J = 8.8 Hz, 2H),6.93 (d, J = 9.0 Hz, 2H), 4.56 (t, J = 7.3 Hz, 1H), 4.28 (t, J = 5.8 Hz 2H), 3.83 (t, J = 5.8 Hz, 2H),2.26 (m, 1H), 1.78 (m, 1H), 0.94 (t, J = 7.4 Hz, 3H); MS (ESI) (m/z) 348.1/350.1(M+H)+.
Statistics shows that (2-Chloroethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 622-86-6.
Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
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