Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54788-38-4, name is 2-Chloro-4-methoxy-1-methylbenzene, A new synthetic method of this compound is introduced below., Formula: C8H9ClO
Acetic anhydride (10 mL) at-10 oC was treated with concentrated nitric acid (>69% pure, 1 mL) and then treated portionwise with 2-CHLORO-4-METHOXY-1-METHYLBENZENE (0. 78G, 5 mmol) at a rate that maintained the internal temperature lower THAN-5 C. The solution was stirred for additional one hour while warming to room temperature, poured into an ice and water mixture, and extracted with ethyl acetate several times. The organic layers were combined, washed with 10% NA2C03 and brine, dried (MGS04), and concentrated under vacuum. The residue was purified by flash column chromatography on silica gel eluting with 9: 1 hexanes/ethyl acetate to provide 0.75g (71%) of the desired product. MS (DCI) m/e 219 (M+NH4) + ; IH NMR (CDC13, 300 MHz) 8 7.78 (s, 1H), 7.09 (s, 1H), 3.94 (s, 3H), 2.35 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ABBOTT LABORATORIES; WO2004/76424; (2004); A1;,
Chloride – Wikipedia,
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