These common heterocyclic compound, 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-(3-Chlorophenyl)ethanamine
2-(1-isopropyl-6-oxo-3-(pyridin-2-yl)piperidin-3-yl)acetaldehyde44B (0.15 g, 0.58 mmol) was dissolved in dichloromethane (10 mL).(3-chlorobenzyl)methylamine is sequentially added thereto(0.098g, 0.69mmol), triethylamine(0.070 g, 0.69 mmol), anhydrous sodium sulfate (0.56 g).After reacting at room temperature overnight, sodium borohydride (0.035 g, 0.86 mmol) was added.Stirring was continued for 2 h, water (20 mL) was added andEtOAc was appliedThe organic phases were combined and washed with a saturated aqueous solution of brine (30 mL×1).Dry over anhydrous sodium sulfate, filter, and concentrate the filtrate.Column chromatography (dichloromethane/methanol = 30:1)Light yellow oily product 5-(2-((3-chlorobenzyl)amino)ethyl)-1-isopropyl-5-(pyridin-2-yl)piperidin-2-one (45A)(0.085 g, 45%).
The synthetic route of 2-(3-Chlorophenyl)ethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
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