In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2533-69-9 as follows. COA of Formula: C3H4Cl3NO
Cl3CC(NH)OMe (1 eq.) was added slowly to a solution of compound (Ql) in AcOH (0.8 M) at 00C, then the reaction mixture was stirred at RT for 2 h. The reaction mixture was diluted with EtOAc, and the resulting organic phase was washed The with sat. aq. NaHCO3 and dried(Na2SO4). Evaporation of the solvent under reduced pressure afforded (75%) the title compound.MS (ES+) C8H4Cl3FN2 required: 252, 254, found: 253, 255 (M+H)+.
According to the analysis of related databases, 2533-69-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; DESSOLE, Gabriella; JONES, Philip; BUFI, Laura, Llauger; MURAGLIA, Ester; ONTORIA ONTORIA, Jesus, Maria; TORRISI, Caterina; WO2010/13037; (2010); A1;,
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