Application of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
95) 8-Bromo-2′-phenoxythiocarbonyladenosine-3′,5′-cyclic boranophosphate, Sp- isomer (Sp-8-Br-2′-PTC-cAMPB. No. 306)A solution of 5 muiotatauiotaomicronIota of Sp-8-Br-cAMPB (example 2) in 2 ml of dry dichloromethane was treated with 2.5 mg of dimethylaminopyridine (Aldrich) and 1 .4 muIota of phenoxythiocarbonyl chloride (Fluka) for 16 h at RT under argon. The decrease of the starting material at 1 :62 min was followed by HPLC (RP-18, 20 Vol.-% acetonitrile, 20 mM triethylammonium formate buffer, 1 .5 ml/min., pH 7 at 259 nm).The peak for Sp-8-Br-2′-PTC-cAMPB at 2:69 min was isolated by semipreparative column chromatography on reversed phase silica (RP-18, 40 Vol.-% acetonitrile, 20 mM triethylammonium formate buffer, 1 .5 ml/min., pH 7), yield 87.6%.C17H18BBrN506PS; MW 542.1 1 UV: max: 259 nm HPLC: 2:69 min.ESI-MS (+): m/z 643/645 [M + 2TEA + H] +^ 629 [M + 2TEA – BH3 + H] + ESI-MS (-): m/z 540/542 [M – H]? 526 [M – BH3 – H] ~ ^ 212 [8-Br-A – H] +
The synthetic route of 1005-56-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH; GENIESER, Hans-Gottfried; WO2012/130829; (2012); A1;,
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