Adding a certain compound to certain chemical reactions, such as: 32943-25-2, name is 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32943-25-2, Product Details of 32943-25-2
A solution of 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine (5.00 g, 21.8 mmol) (The Journal of Biological Chemistry (2009) 285, 11, 8363-8374) in toluene (50.0 mL) was treated with chloropropionyl chloride (2.18 mL, 22.9 mmol) and heated to 100 C for 1 h. The mixture was cooled to 25 C, concentrated under N2 stream, dissolved in a minimal amount of toluene and purified by flash chromatography (SiO2, 5-20% ethyl acetate-hexanes) to afford the title compound as an off-white solid (4.74 g, 68%). 1H NMR (600 MHz, CDCl3) (mixture of rotamers) 7.38 (1H, s), 7.29 (2H, br m), 7.25 (1H, m), 7.20 (1H, m), 7.14 (1H, m), 7.06 (1H, d, J = 8.2 Hz), [2H, 3.82 (br m), 3.77 (br m)], [2H, 3.39(br m), 3.33 (br m), 3.29 (t, J = 4.7 Hz)], 2.81 (3H, m), [1H, 2.57(t, J = 6.7 Hz), 2.53 (t, J = 6.8 Hz), 2.50 (t, J = 6.6 Hz)]; LCMS m/z 320.4 ([M + H+], C17H15Cl2NO requires 320.1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine, and friends who are interested can also refer to it.
Reference:
Article; Kastrinsky, David B.; Sangodkar, Jaya; Zaware, Nilesh; Izadmehr, Sudeh; Dhawan, Neil S.; Narla, Goutham; Ohlmeyer, Michael; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6528 – 6534;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics