In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 81927-55-1 as follows. Application In Synthesis of Benzyl 2,2,2-trichloroacetimidate
To a solution of scheme 58 compound Si (24 g, 0136 mol) and benzyl 2,2,2- thchioroaceiirnidate (5 1)3 g, 0204 inol) in cvchexanedichloromethane (600 inL120 ml..) at room temperature was added tritluorornethanesulfonic anhydride (cat. 1 .2 mE) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed 4lth sat N& K (Y and hnne, dned o ci anh chous Na2SO- filteted and ctncentiated he residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl aceiate =10: 1) to give the title compound (35 g, 933% yield) as a yellow oil.
According to the analysis of related databases, 81927-55-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason Allan; PHADKE, Avinash S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (358 pag.)WO2017/35411; (2017); A1;,
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