Application of 1435-50-3, A common heterocyclic compound, 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, molecular formula is C6H3BrCl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound4-(4-(3-ethynyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (0.20 g) , 0.51 mmol) was suspended in DMF (15 mL), and then Pd(PPh3)2Cl2 (36 mg, 0.051 mmol), CuI (10 mg, 0.051 mmol) and1,4-Dichloro-2-bromobenzene (0.12 g, 0.51 mmol). After the reaction liquid is exchanged for three times (nitrogen),Et3N (1.4 mL, 10.2 mmol) was added. After the reaction solution was stirred at 75 C for 2 hours under a nitrogen atmosphere,The organic layer was concentrated under reduced pressure. EtOAc (EtOAc)The organic phase obtained by liquid separation was dried over anhydrous Na2SO?The residue was subjected to silica gel column chromatography(PE/EtOAc(v/v)=1/2)Purification to give the title compound as a yellow solid(0.17 g, 62%).
The synthetic route of 1435-50-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Xiaobo; Zhou Shiqing; (62 pag.)CN103833753; (2017); B;,
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