50638-46-5, name is 4-Bromo-3-chloroanisole, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: chlorides-buliding-blocks
Step 2: (E)-tert-Butyl 3-(4-((E)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutyl-l-(4- morpholinophenyl)vinyl)phen l)acrylate[00401] A mixture of (E)-tert-butyl 3-(4-((Z)-2-cyclobutyl-2-(5,5-dimethyl-l ,3,2-dioxaborinan-2- yl)-l-(4-morpholinophenyl)vinyl)phenyl)acrylate (754 mg, 1.64 mmol), l -bromo-2-chloro-4- methoxybenzene (545 mg, 2.46 mmol), Pd(PPh3)2Cl2(1 15 mg, 0.16 mmol), and KOH (6M, 1.6 mL, 9.9 mmol) in 1 ,4-dioxane (10 mL) was heated to 90C for lh. After cooling, ethyl acetate and brine were added to the reaction mixture and the two layers were separated. The organic layer was washed with more brine, dried over sodium sulfate, filtered and evaporated to dryness. The residue was purified by flash chromatography on silica gel to afford 520 mg of the title compound as a yellow foam. 1H NMR (400 MHz, DMSO-d6): delta 7.37-7.33 (m, 3H), 7.1 1 (d, 1H), 7.04 (d, 2H), 6.95-6.90 (m, 5H), 6.82 (m, 1H), 6.34 (d, 1H), 3.74 (m, 4H), 3.71 (s, 3H), 3.42 (m, 1H), 3.13 (m, 4H), 1.87 (m, 3H), 1.67 (m, 2H), 1.46 (m, 1H), 1.43 (s, 9H); LCMS: 586 (M+H)+.
The synthetic route of 50638-46-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SERAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; GOVEK, Steven, P.; KAHRAMAN, Mehmet; BONNEFOUS, Celine; JULIEN, Jackaline, D.; WO2014/151899; (2014); A1;,
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