Reference of 38762-41-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38762-41-3 as follows.
8-(4-Bromo-2-chloro-phenylamino)-imidazo[l,5-alpyridine-7- carboxylic acid methyl ester[00245] A suspension of 8-chloro-imidazo[ 1 ,5-a]pyridine-7-carboxylic acid methyl ester(300 mg, 1.43 mmol), 4-bromo-2-chloroaniline (354 mg, 1.72 mmol), Pd2dba3 (65 mg, 0.07 mmol), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (131 mg, 0.28 mmol) and K3PO4 (424 mg, 2.00 mmol) in toluene (5 ml) was degassed and then heated at HO0C for 18 hours. The reaction mixture was then cooled to room temperature and diluted with ethyl acetate. The resultant mixture was washed with water and brine, then loaded onto a 10 g Isolute SCX-2 cartridge which was eluted with methanol and then a 2M solution of ammonia in methanol. The appropriate fractions were combined and concentrated in vacuo. The resultant residue was subjected to flash chromatography (Si-PPC, gradient 0% to 100%, ethyl actetate in DCM) to afford the title compound as a yellow oil (271 mg, 50%). LCMS (method B): Rx = 3.65 min, [M+H]+ = 381/383.
According to the analysis of related databases, 38762-41-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; WO2009/85980; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics