Reference of 57310-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57310-39-1 as follows.
Step 1: Synthesis of 1-bromo-2-chloro-5-methyl-4-nitrobenzene (8A) A solution of compound 2-bromo-1-chloro-4-methylbenzene (50 g, 0.24 mol, 1 eq) in conc.H2SO4 (400 ml), was cooled to 0-5 C. using an ice-water-methanol bath. Fuming nitric acid (10.38 ml, 1.48 g/ml, 0.24 mol) in con.H2SO4 (26 ml) was slowly added dropwise to the mixture and then stirred at 0 C. for 3 h. The solution was poured into 500 g ice/water and extracted with dichloromethane (2*300 mL). The combined organic layers were washed with water, dried over Na2SO4 and concentrated to give 58 g of 8A which was used the next step directly without further purification. 1H NMR (400 MHz, DMSO-d6) delta 8.09 (s, 1H), 7.64 (s, 1H), 2.57 (s, 3H).
According to the analysis of related databases, 57310-39-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio G.; US2013/116263; (2013); A1;,
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