Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 821-10-3, name is 1,4-Dichlorobut-2-yne, A new synthetic method of this compound is introduced below., Quality Control of 1,4-Dichlorobut-2-yne
1,4-Dichloro-2-butyne (16) (1.26 mL, 13.1 mmol) was added to a solution of malonate 15 (2.50 g, 8.73 mmol) and K2CO3 (3.62 g, 26.2mmol) in MeCN (60 mL) at room temperature. The reaction mixture was stirred for 12h at 90 C, and then H2O (30 mL) was added at 0 C. The resultant mixture was extracted with Et2O (30 mL×3), and the combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography on silica gel (30 g, n-hexane/EtOAc 4/1) to afford chloride 18 (2.54 g, 6.81mmol) in 78% yield.
The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Masuda, Keisuke; Tanigawa, Masashi; Nagatomo, Masanori; Urabe, Daisuke; Inoue, Masayuki; Tetrahedron; vol. 73; 26; (2017); p. 3596 – 3605;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics