Electric Literature of 102-49-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-49-8, name is 3,4-Dichlorobenzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: In a 50mL round bottom flask, Compound 6 (0.5g, 0.6698mmol), potassium iodide (1.11g, 0.698mmol), and cyclopropylamine (2.43mL, 2.00g, 35mmoL) in isopropanol (5mL) was shocked to dissolve at 50°C. The reaction was insulated. Reaction progress was monitored by TLC. After reaction completion, it was concentrated. The residue was dissolved in water (50mL) and ethyl acetate (100mL). The aqueous layer was washed with ethyl acetate (3 × 50mL). The combined organic phases was washed with saturated aqueous sodium bicarbonate (50mL) and brine (40mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated to give the crude product. Purified by chromatography on silica gel eluting with methanol:dichloromethane:ammonia (4:95.6:0.4 to 6:93.5:0.4) to give 0.38g of the title compound (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropylamino)methyl]-alpha-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-hexylxylopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one For Examples 5 to 80, R is described in Table 1 and R in nitrogen or sulfur are directly connected to R3 methylene. R’ is H for Examples 5 to 80. Example 5 prepared according to General Procedure 1, General Procedure 2, and General Procedure 3 was followed for Examples 6-80 with specific reaction time and basis listed in the table. In the table, structure, yield and mass spectrometry ( “MassSpec”) data are given for the final compound.
The synthetic route of 3,4-Dichlorobenzylamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pulike Biological Engineering, Inc.; Liu, Xingjin; Zhang, Xuke; (77 pag.)CN105669798; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics