Application of 932-96-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-96-7, name is 4-Chloro-N-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(a) 5-r(4-Chlorophenv0methylamino]pyridine-2-carbaldehvde The sub-title compound was prepared from 5-bromo-2-formylpyridine and 4-chloro-Lambda/-methylaniline. Toluene (e.g.100 mL) and 4-chloro-Lambda/~methylaniline (e.g. 37.8 mmol) may be added to a mixture of Cs2CO3 (e.g. 53 mmol), Pd(OAc)2 (e.g. 1.9 mmol), BINAP (e.g. 2.8 mmol) and 5-bromo-2-formylpyridine (e.g. 37.8 mmol). The mixture may be stirred at 85 0C for 20 h and filtered through Celite. The solids may be washed with EtOAc. The combined filtrates may be concentrated and the residue purified by chromatography to give the sub-title compound.
The synthetic route of 4-Chloro-N-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOLIPOX AB; NILSSON, Peter; PELCMAN, Benjamin; KATKEVICS, Martins; WO2010/103297; (2010); A2;,
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