Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67952-93-6, name is 3-Chloro-4-methylbenzylamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 67952-93-6
General procedure: Under an Ar atmosphere, to a solution of benzylamine 1a (0.55 mL, 5 mmol) in 20 mL of CH2Cl2, FeCl3 (811 mg, 5.0 mmol) and m-CPBA (2.2 g, 10.5 mmol, 85%) were added successively at 0 C. The reaction mixture was stirred at 0 C for 3h (TLC monitoring) and quenched with saturated aqueous Na2S2O3 (10 mL). Then, 10% NaOH solution (15 mL) and H2O (15 mL) were added and the mixture wasextracted with CH2Cl2. The combined extracts were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate as eluant to give the light yellow liquid product of N,N-dichlorobenzylamine 2a 850 mg (97%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67952-93-6.
Reference:
Article; Liu, Jia; Xu, Junchao; Ren, Jiangmeng; Zeng, Bu-Bing; Chemistry Letters; vol. 43; 2; (2014); p. 190 – 192;,
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