Related Products of 220227-21-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 220227-21-4 as follows.
Into a 100-mL round-bottom flask, were placed 3-(chloromethyl)-1 ,2,4-thiadiazol-5-amine (1 .00 g, 6.68 mmol, 1 .00 equiv), N,N-dimethylformamide (30 m L), sodium hydride (242 mg, 10.08 mmol, 1 .50 equiv), 2,4,5-trifluorobenzene-1 -sulfonyl chloride (1 .85 g, 8.02 mmol, 1 .00 equiv). The resulting solution was stirred for 1 .5 h at room temperature. The reaction was then quenched by the addition of water. The resulting solution was extracted with ethyl acetate and the organic layers combined. The resulting mixture was washed with brine, dried and concentrated under vacumm. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 :6). This resulted in 700 mg (30%) of N-[3- (chloromethyl)-l ,2, 4-thiadiazol-5-yl]-2, 4, 5-trifluorobenzene-1 -sulfonamide as a yellow solid.
According to the analysis of related databases, 220227-21-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ZALICUS PHARMACEUTICALS, LTD.; SHORT, Glenn, F., III; ROMERO, Donna, L.; LEE, Margaret, S.; WO2015/130957; (2015); A1;,
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