Electric Literature of 6781-98-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6781-98-2, name is 2-Chloro-1,3-dimethylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: In a schlenk tube with a magnetic bar, 6a (40 mg, 6 mol percent), Pd(OAc)2 (5.4 mg, 3 mol percent), and K3PO4 (594 mg, 2.8 mmol) in 5 mL of THF/H2O (5:1) were placed under argon. Aryl chloride (0.8 mmol) was added via syringe and followed by adding phenylboronic acid (1.2 mmol). The resulting mixture was stirred at room temperature for 12 h. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (petroleum ether/EtOAc=100:1) to give the desired product.
The synthetic route of 2-Chloro-1,3-dimethylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Taoping; Zhao, Xiaoming; Shen, Qilong; Lu, Long; Tetrahedron; vol. 68; 32; (2012); p. 6535 – 6547;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics