In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-57-4, name is 2-Bromo-5-chloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrClN
2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (50 wtpercentsolution in ethyl acetate, 8.1 mL, 13.6 mmol) was added slowly to a stirred solution of2-15 bromo-5-chloroaniline (1.5 g, 7.27 mmol), thiane-4-carboxylic acid (1.0 g, 6.84 mmol)and pyridine (2.7 mL, 33.4 mmol) in ethyl acetate (14 mL) at ooc under nitrogen. Thereaction mixture was allowed to warm slowly to 20°C and stirred for 64 h. The resultantsuspension was diluted with ethyl acetate (20 mL) and quenched with water (30 mL).The solids were collected by filtration, washing sequentially with ethyl acetate (2 x 2020 mL), water (20 mL) and diethyl ether (2 x 20 mL). The solids were dried at 50°C invacuo for 16 h, to afford the title compound (2.08 g, 86percent) as a pink powder. DH (500MHz, DMSO-d6) 9.51 (br s, 1H), 7.71-7.65 (m, 2H), 7.21 (dd, J8.6, 2.6 Hz, 1H), 2.71-2.62 (m, 4H), 2.57 (tt, J 11.5, 3.1 Hz, 1H), 2.19-2.08 (m, 2H), 1.78-1.63 (m, 2H). HPLCMS(method 5): MH+ m/z 334, RT 1.90 minutes.
The synthetic route of 823-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; DEBOVES, Herve Jean Claude; FOLEY, Anne Marie; FOULKES, Gregory; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; QUINCEY, Joanna Rachel; SCHULZE, Monika-Sarah Elisabeth Dorothea; SELBY, Matthew Duncan; SMALLEY, Adam Peter; TAYLOR, Richard David; TOWNSEND, Robert James; ZHU, Zhaoning; (278 pag.)WO2018/229079; (2018); A1;,
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