In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Benzyl 2,2,2-trichloroacetimidate
To a solution of Scheme 5-7 compound SI (24 g, 0. 136 mol) and benzyl 2,2,2- trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 niL) at room temperature was added triiluoromeihanesulfomc anhydride (cat. L2 mi..) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHC03 and brine, dried over anhydrous Na2Si, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (S2) (35 g, 93.3% yield) as a yellow oil.
The synthetic route of 81927-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (333 pag.)WO2017/35401; (2017); A1;,
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