Reference of 7006-52-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7006-52-2, name is N-Methyl-3-chloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
3-Chloro-N-methylaniline (0.47 mL, 3.90 mmol) and anhydrous NaHCO3 (1.94 g) were ground together into fine powder, and commercially available benzenesulfonylchloride 6 (915 mg, 3.88 mmol) was added under vigorous stirring at room temperature. The progress of reaction was monitored by TLC until the conversion of amine was completed. After 30 min., the reaction mixture was diluted with water, acidified with 1N aqueous HCl, extracted several times with Et2O and the combined organic phase was dried over anhydrous sodium sulphate. Evaporation under vacuum of the organic solvent afforded a crude product corresponding to the sulfonamidic derivative.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Methyl-3-chloroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Granchi, Carlotta; Roy, Sarabindu; Mottinelli, Marco; Nardini, Elisa; Campinoti, Fabio; Tuccinardi, Tiziano; Lanza, Mario; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Martinelli, Adriano; MacChia, Marco; Minutolo, Filippo; Bioorganic and Medicinal Chemistry Letters; vol. 21; 24; (2011); p. 7331 – 7336;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics