Extracurricular laboratory: Synthetic route of 5-Chloro-1H-benzo[d][1,2,3]triazole

Statistics shows that 5-Chloro-1H-benzo[d][1,2,3]triazole is playing an increasingly important role. we look forward to future research findings about 94-97-3.

Synthetic Route of 94-97-3, These common heterocyclic compound, 94-97-3, name is 5-Chloro-1H-benzo[d][1,2,3]triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 35-mL Schlenk tube, equipped with a magnetic stirring bar, was charged with 9H-xanthene 1a (137 mg, 0.75 mmol), 1H-benzo[d][1,2,3]triazole 2a (60 mg, 0.5 mmol), and BPO (242 mg, 1.0 mmol), followed by the addition of DCE (5.0 mL). The mixture was stirred at 80 C for 6 h; then it was quenched with saturated aqueous Na2S2O3 (2.0 mL), saturated aqueous K2CO3 (2.0 mL), and water (20.0 mL), and extracted with CH2Cl2 (20.0 mL) three times. The residue obtained after evaporation of the solvent was purified by column chromatography on silica gel (petroleum ether/ethyl acetate = 12:1, v/v) to afford 1-(9H-xanthen-9-yl)-1H-benzo[d][1,2,3]triazole 3a as a colorless crystal (144 mg, 96% yield).

Statistics shows that 5-Chloro-1H-benzo[d][1,2,3]triazole is playing an increasingly important role. we look forward to future research findings about 94-97-3.

Reference:
Article; Li, Yanni; Li, Yanping; Li, Yuan; Chen, Chunlin; Ying, Fengyuan; Dong, Ying; Liang, Deqiang; Synthetic Communications; vol. 49; 16; (2019); p. 2053 – 2065;,
Chloride – Wikipedia,
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