Synthetic Route of 622-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 622-86-6 as follows.
5.23mL of 1-(2-chloroethoxy)benzene (38.45mmol), previously distilled on CaH2, were dissolved in 50mL of dry THF to give a colorless solution. 25mL of a solution 2M of sodium cyclopentadienide in THF were added drop-wise at -78C. The solution was warmed up to room temperature and left stirred overnight to give a white precipitate and a dark pink solution. Afterwards the mixture was quenched with methanol and cold water. The organic product was extracted by 3x 50mL ether fraction. The solution was dried over magnesium sulphate and had its solvent removed at reduced pressure to yield a brown oil (yield 89%). 1H NMR (300MHz, CDCl3) delta 2.88 [t, 2H, C5H5-(CH2CH2OC6H5),], 4.14 [t, 2H, C5H5-(CH2CH2OC6H5)], 3.01-3.20 [m, 1H, C5H5-(CH2CH2OC6H5)], 6.17-6.52 [m, 4H, C5H5-(CH2CH2OC6H5)], 6.92-7.32 [m, 5H, C5H5-(CH2CH2OC6H5)]. 13C NMR (75MHz, C6D6) delta 30.1 [C5H5-(CH2CH2OPh)], 67.8 [C5H5-(CH2CH2OPh)], 44.1 [C5H5-(CH2CH2OPh)], 114.8, 120.9, 128.1, 129.7, 134.4, 134.9, 159.1 [C5H5-(CH2CH2OPh)]. Mass (GC-MS): 186.1 [M]+.
According to the analysis of related databases, 622-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Saturnino, Carmela; Sirignano, Esther; Botta, Antonio; Sinicropi, Maria Stefania; Caruso, Anna; Pisano, Assunta; Lappano, Rosamaria; Maggiolini, Marcello; Longo, Pasquale; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 136 – 140;,
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