Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, A new synthetic method of this compound is introduced below., Recommanded Product: Benzyl 2,2,2-trichloroacetimidate
[0484] To a solution of Scheme 5-8 compound SI (24 g, 0.136 mol) and benzyl 2,2,2- trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 ml.,) at room temperature was added trifJuoromethanesuifonic anhydride (cat. 1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight, and filtered. The filtrate was washed with sat. NaHCCb, brine, dried over anhydrous Nay.SO-i, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate 10. 1 ) to afford the title compound (35 g, 93.3% yield) as a yellow oil .
The synthetic route of 81927-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (325 pag.)WO2017/35405; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics