Adding a certain compound to certain chemical reactions, such as: 873-38-1, name is 2-Bromo-4-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 873-38-1, category: chlorides-buliding-blocks
Step 1: 2-Bromo-4-chloroaniline (1.0 eq) was dissolved in CH2Cl2 (0.25 M), then triethylamine and trifluoroacetyl anhydride (1.1 eq each) were added. The resulting mixture was stirred at room temperature for 1 hour. The solvent was evaporated and the residue was purified by flash chromatography with CH2Cl2 as eluent to give the amide in 97% yield. m/z(M-H)- 300.0
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Reference:
Patent; ZIARCO PHARMA LIMITED; LIU, Wai Leung; PURKINS, Lynn; YEADON, Michael; (23 pag.)US2017/7576; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics