Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7006-52-2, name is N-Methyl-3-chloroaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H8ClN
General procedure: Bi(NO3)3.5H2O (2 equiv, 0.6 mmol), Pd(OAc)2 (0.015 mmol, 5 mol percent) were added into a 25mL oven-dried Schlenk tube, the tube was evacuated and backfilled with Ar (repeated three times in 30 min). Under a counter flow of Ar, N-substituted aniline (1 equiv, 0.3 mmol) was added by syringe firstly, 1.5 mL TFE and 0.5 mL TFA were then added by disposable medical syringes. The flask was sealed and the mixture was stirred firstly at room temperature for15 min, then allowed to stir in a preheated oil bath at 90 °C for 24 h.The mixture was cooled to room temperature when the reaction was completed. Next, the solution was diluted by 10 mL ethyl acetate and filtered the insoluble matters, washed the organic phases by 5percent NaHCO3 solution after the extraction, and extracted the aqueous phases by ethyl acetate (3×15 mL) to collect organic phases. All the organic solutions were washed by brine, dried 30 min with anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude products were purified by chromatography on silica gel, eluting with ethyl acetate/petroleum ether(5/1-2/1).
According to the analysis of related databases, 7006-52-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Feng, Yi-Si; Mao, Long; Bu, Xiao-Song; Dai, Jian-Jun; Xu, Hua-Jian; Tetrahedron; vol. 71; 23; (2015); p. 3827 – 3832;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics