Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, Product Details of 61881-19-4
To a solution of 28 (0.91 g, 1.7 mmol) in acetone (17 mL) wereadded CF3C(=NPh)Cl (0.53 mL, 3.3 mmol) and K2CO3 (1.1 g,8.3 mmol) at 0 C. After stirring for 2.5 h at the same temperature, thecompletion of the reaction was confirmed by TLC (5:1 n-hexane/EtOAc). The reaction mixture was filtered through Celite pad and thepad was washed with CHCl3. The filtrate and washings were concentrated.The resulting residue was purified by silica gel columnchromatography (25:1 n-hexane/EtOAc) to give 29 (1.2 g, quant.) ascolorless syrup. 1H NMR (500 MHz, CDCl3) delta 7.44-6.70 (m, 17H, Ar),5.08-4.83 (br m, 4H, H-1, H-2, H-3, H-4), 4.15-3.65 (br m, 3H, H-5, H-6a, H-6b), 1.08 (s, 9H, tBu), 1.01 (s, 9H, tBu); 13C NMR (125 MHz,CDCl3) delta 143.5, 143.3, 138.9, 138.6, 135.4, 135.3, 135.3, 135.2, 133.1,133.1, 128.7, 128.4, 128.4, 128.3, 128.2, 128.2, 128.1, 128.1, 128.0,127.9, 127.7, 127.7, 127.7, 126.9, 126.5, 126.2, 126.1, 126.1, 126.0,126.0, 125.6, 124.4, 119.4, 119.2, 84.0, 81.2, 80.0, 77.9, 77.7, 77.5,75.8, 75.5, 75.5, 73.9, 71.0, 68.8, 66.5, 66.2, 27.4, 27.0, 26.9, 22.7,20.0. HRMS (ESI) m/z: found [M+Na]+ 744.2935, C40H46F3NO6Sicalcd for [M+Na]+ 744.2939.
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Reference:
Article; Takato, Koichi; Kurita, Motoki; Yagami, Nahoko; Tanaka, Hide-Nori; Ando, Hiromune; Imamura, Akihiro; Ishida, Hideharu; Carbohydrate Research; vol. 483; (2019);,
Chloride – Wikipedia,
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