In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-86-6, name is (2-Chloroethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (2-Chloroethoxy)benzene
2-(4-Aminophenyl) butanoic acid (Compound 10, step 1) (397.3 mg, 2.0 mmol) was suspended with stirring intrifluoroacetic anhydride (277.4 uL, 2.0 mmol). Then (2-chloroethoxy)benzene(252.4 uL, 1.8 mmol) was added dropwise and the resulting mixture was stirredat room temperature overnight. The reaction was quenched with saturated sodiumbicarbonate solution (5 mL) and extracted with ethyl acetate (2 x 15 mL). The combined organic layers were dried overanhydrous magnesium sulfate and concentrated on a rotary evaporator. The resulting residue was purified byreverse-phased chromatography (C-10 column, gradient of acetonitrile in waterwith 0.1% formic acid) to afford 297.1 mg (49%) of the desired product as ayellow solid. 1H NMR (400MHz, MeOD) delta 7.99 (d, J = 8.9 Hz, 2H), 7.28 (m, 4H), 6.96 (d, J = 8.9 Hz, 2H),4.58 (t, J = 7.2 Hz,1H), 4.27 (t, J = 5.5 Hz, 2H), 3.84 (t, J = 5.5 Hz, 2H),2.11 (m, 1H), 1.78 (m, 1H), 0.88 (t, J = 7.3 Hz 3H); MS (ESI) (m/z) 318.1/320.1(M+H)+.
The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
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